Relative Biological Effectiveness of Carbon Ions for Head-and-Neck Squamous Cell Carcinomas According to Human Papillomavirus Status.
Naoto OsuDaijiro KobayashiKatsuyuki ShiraiAtsushi MushaHiro SatoYuka HirotaAtsushi ShibataTakahiro OikeTatsuya OhnoPublished in: Journal of personalized medicine (2020)
Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPV-positive HNSCCs.
Keyphrases
- high grade
- induced apoptosis
- cell cycle arrest
- randomized controlled trial
- early stage
- prognostic factors
- cervical cancer screening
- systematic review
- squamous cell
- endoplasmic reticulum stress
- radiation therapy
- oxidative stress
- signaling pathway
- electronic health record
- deep learning
- radiation induced
- big data
- living cells
- glycemic control