Targeting peroxisome proliferator-activated receptor γ proteasomal degradation by magnolol is a potential avenue for adipogenesis-mediated metabolic homeostasis.

Peng-Long LiMei LiZhenya WangXiao-Ming WangShuai-Yang LiuSong TianZhou-Xiang WangXu ChengYufeng HuPeng ZhangZhi-Gang SheHailong YangHongliang LiXiao-Jing Zhang

Published in: Obesity (Silver Spring, Md.) (2023)

The downregulation of K11-linked ubiquitination of PPARγ caused by FBOX9 is essentially required for adipogenesis, while targeting PPARγ-FBXO9 interaction provides a new avenue for the therapy of adipogenesis-related metabolic disorder.

Keyphrases

high fat diet induced
insulin resistance
cancer therapy
cell proliferation
fatty acid
type diabetes
risk assessment
human health
mesenchymal stem cells
drug delivery
skeletal muscle
bone marrow