Antizyme Inhibitor 2-Deficient Mice Exhibit Altered Brain Polyamine Levels and Reduced Locomotor Activity.
Ana LambertosMaría Ángeles Núñez-SánchezCarlos López-GarcíaAndrés Joaquín López-ContrerasBruno Ramos-MolinaRafael PeñafielPublished in: Biomolecules (2022)
Our study revealed that AZIN2 expression in the brain is particularly limited to the cerebellum. In addition, the ablation of Azin2 leads to a reduction in putrescine that relates to alterations in motor function, suggesting the role of AZIN2 in the functioning of dopaminergic neurons.