Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.

Muhammad Saqib NawazRazia AsgharNashaiman PervaizShahid AliIrfan HussainPeiqi XingYiming BaoAmir Ali Abbasi

Published in: BMC evolutionary biology (2020)

Conclusively, the critical protein segment of UCHL1 identified in the present study not only demonstrates the relevant role of intraprotein conformational epistasis in the pathophysiology of PD but also offers a novel therapeutic target for the disease.

Keyphrases

endothelial cells
genome wide
molecular dynamics
copy number
induced pluripotent stem cells
small molecule
brain injury
pluripotent stem cells
amino acid
genome wide identification