Association between disease-modifying antirheumatic drugs for rheumatoid arthritis and risk of incident dementia: a systematic review with meta-analysis.
Wen-Hui XieYue HouShiyu XiaoXiaolin ZhangZhuoli ZhangPublished in: RMD open (2024)
Biological DMARDs for RA are associated with decreased dementia risk, while protective effect is not observed in conventional synthetic DMARDs. Controlled clinical trials on TNF inhibitors are necessary to test their neuroprotective potentials.
Keyphrases
- rheumatoid arthritis
- disease activity
- rheumatoid arthritis patients
- mild cognitive impairment
- clinical trial
- cognitive impairment
- ankylosing spondylitis
- interstitial lung disease
- cardiovascular disease
- systemic lupus erythematosus
- cerebral ischemia
- phase ii
- open label
- systemic sclerosis
- brain injury
- subarachnoid hemorrhage
- study protocol