Universal promoter scanning by Pol II during transcription initiation in Saccharomyces cerevisiae.

Chenxi QiuHuiyan JinIrina VvedenskayaJordi Abante LlenasTingting ZhaoIndranil MalikAlex M VisbiskyScott L SchwartzPing CuiPavel ČabartKang Hoo HanWilliam K M LaiRichard P MetzCharles D JohnsonSing-Hoi SzeB Franklin PughBryce E NickelsCraig D Kaplan

Published in: Genome biology (2020)

Our observations coupled with previous data validate key predictions of the scanning model for Pol II initiation in yeast, which we term the shooting gallery. In this model, Pol II catalytic activity and the rate and processivity of Pol II scanning together with promoter sequence determine the distribution of TSSs and their usage.

Keyphrases

saccharomyces cerevisiae
high resolution
transcription factor
dna methylation
electron microscopy
gene expression
preterm infants
electronic health record
mass spectrometry
artificial intelligence
preterm birth