Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15.
Sheila K PatelElena VelkoskaDaniel GayedJay RamchandJessica LesmanaLouise M BurrellPublished in: BMC nephrology (2018)
This is the first evidence that loss of cardiac KLF15 in CKD induced LVH is associated with unchecked trophic and fibrotic signalling, and that ACE inhibition ameliorates loss of cardiac KLF15.
Keyphrases
- left ventricular
- chronic kidney disease
- end stage renal disease
- transcription factor
- heart failure
- hypertrophic cardiomyopathy
- poor prognosis
- cardiac resynchronization therapy
- mitral valve
- systemic sclerosis
- aortic stenosis
- high glucose
- left atrial
- diabetic rats
- oxidative stress
- angiotensin ii
- idiopathic pulmonary fibrosis
- endothelial cells
- peritoneal dialysis
- transcatheter aortic valve replacement
- catheter ablation