TET3-mediated DNA demethylation modification activates SHP2 expression to promote endometrial cancer progression through the EGFR/ERK pathway.

Fen Xue Lifen Liu Xueqiang Tao Weipei Zhu

Published in: Journal of gynecologic oncology (2024)

TET3 promoted the DNA demethylation modification in the SHP2 promoter and activated SHP2, thus activating the EGFR/ERK pathway and leading to EC progression.

Keyphrases

endometrial cancer
signaling pathway
small cell lung cancer
circulating tumor
epidermal growth factor receptor
tyrosine kinase
cell free
single molecule
pi k akt
cell proliferation
poor prognosis
dna methylation
gene expression
transcription factor
nucleic acid
circulating tumor cells