Increased TOX expression concurrent with PD-1, Tim-3, and CD244 in T cells from patients with non-Hodgkin lymphoma.
Shuxin HuangChaofeng LiangYujie ZhaoTairan DengJiaxiong TanYuhong LuSichu LiuYangqiu LiShaohua ChenPublished in: Asia-Pacific journal of clinical oncology (2021)
Higher expression of TOX concurrent with PD-1, Tim-3, and CD244 in T cells from patients with B-NHL may contribute to T cell exhaustion and impair their special anti-tumor T cell activity. TOX may be considered a potential target for reversing T cell exhaustion and improving T cell function in hematological malignancies.