Evaluation of in vitro and in vivo Efficacy of a Novel Amphotericin B-Loaded Nanostructured Lipid Carrier in the Treatment of Leishmania braziliensis Infection.
Jéssica Rebouças-SilvaMaraine Catarina TadiniDanielle Devequi Gomes NunesAna Luíza MansurPaulo S Silveira-MattosCamila I de OliveiraFabio Rocha FormigaAndresa A BerrettaFranciane Marquele-OliveiraValéria Matos BorgesPublished in: International journal of nanomedicine (2020)
Here, we preliminarily demonstrate the effectiveness of an innovative and cost-effective AmB-NLC formulation in promoting the killing of intracellular L. braziliensis. This novel carrier system could be a promising alternative for the future treatment of cutaneous leishmaniasis.