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Evaluation of in vitro and in vivo Efficacy of a Novel Amphotericin B-Loaded Nanostructured Lipid Carrier in the Treatment of Leishmania braziliensis Infection.

Jéssica Rebouças-SilvaMaraine Catarina TadiniDanielle Devequi Gomes NunesAna Luíza MansurPaulo S Silveira-MattosCamila I de OliveiraFabio Rocha FormigaAndresa A BerrettaFranciane Marquele-OliveiraValéria Matos Borges
Published in: International journal of nanomedicine (2020)
Here, we preliminarily demonstrate the effectiveness of an innovative and cost-effective AmB-NLC formulation in promoting the killing of intracellular L. braziliensis. This novel carrier system could be a promising alternative for the future treatment of cutaneous leishmaniasis.
Keyphrases
  • drug delivery
  • randomized controlled trial
  • systematic review
  • current status
  • cancer therapy