Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses.

Zhaonan Zou Michio Iwata Yoshihiro Yamanishi Shinya Oki

Published in: BMC bioinformatics (2022)

Our proposed approach has the potential to elucidate the MoAs for both approved drugs and candidate compounds from an epigenetic perspective, thereby revealing new therapeutic targets, and to guide the discovery of unexpected therapeutic effects, side effects, and novel targets and actions.

Keyphrases

single cell
high throughput
dna methylation
gene expression
rna seq
genome wide
small molecule
electronic health record
big data
human health
risk assessment
drug administration
machine learning
high throughput sequencing