Interpreting the lipidome: bioinformatic approaches to embrace the complexity.

Jennifer E KyleLucila AimoAlan J BridgeGeremy C ClairMaria S FedorovaJ Bernd HelmsMartijn R MolenaarZhixu NiMatej OresicDenise N SlenterEgon L WilighagenBobbie-Jo M Webb-Robertson
Published in: Metabolomics : Official journal of the Metabolomic Society (2021)
Here we describe six approaches that capture three core focus areas for lipidomics: (1) lipidome annotation including a resolvable database identifier, (2) interpretation via pathway- and enrichment-based methods, and (3) understanding complex interactions to emphasize specific steps in the analytical process and highlight challenges in analyses associated with the complexity of lipidome data.