Treatment options for HER2-expressing colorectal cancer: updates and recent approvals.
Binbin Zheng-LinTanios S Bekaii-SaabPublished in: Therapeutic advances in medical oncology (2024)
Colorectal cancer is a leading cause of cancer-related mortality worldwide. Approximately 3-5% of colorectal tumors harbor human epidermal growth factor receptor ( HER2 ) amplification which is associated with a higher incidence of intracranial metastasis and overall worse outcomes. In the setting of refractory metastatic RAS wild-type tumors, evidence supports the use of various HER2-blocking agents, including monoclonal antibodies, tyrosine kinase inhibitors, and novel antibody-drug conjugates. With a number of relatively active agents clinically available and even more in development, it is crucial for clinicians to familiarize themselves with the mechanisms of action, efficacy data, and safety profiles of these treatments. In this review, we aim to summarize key findings from past and ongoing trials with anti-HER2 agents in metastatic colorectal cancer.
Keyphrases
- wild type
- epidermal growth factor receptor
- metastatic colorectal cancer
- tyrosine kinase
- advanced non small cell lung cancer
- endothelial cells
- risk factors
- small cell lung cancer
- cardiovascular events
- palliative care
- big data
- coronary artery disease
- type diabetes
- machine learning
- induced pluripotent stem cells
- cancer therapy
- drug delivery
- pluripotent stem cells