Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site.
Valentina Noemi MadiaDavide IalongoElisa PatacchiniCécile ExertierLorenzo AntonelliGianni ColottiAntonella MessoreValeria TudinoFrancesco SaccolitiLuigi ScipioneAndrea IlariRoberta CostiRoberto Di SantoPublished in: Molecules (Basel, Switzerland) (2023)
were the most potent inhibitors found, suggesting that an additional aromatic ring might be promising for enzymatic inhibition. Further structure-activity relationships are needed to optimize our compounds activity.
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