TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity.
Hui LuYingze HuangXiaofang NiTengfei MaTeding ChangMan LiuNijie LiPeijiang LuPing YuanLin LiuFei ShiJuanjuan XiaoHan XiaoQiuhong DuanFeng ZhuPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)
T-lymphokine-activated killer cell-originated protein kinase promotes the development of psoriasis. Therefore, TOPK might be a promising drug target for the prevention and treatment of psoriasis. Worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity, providing new strategies for clinical intervention.