Association of Increased Serum Lipopolysaccharide but not Microbial Dysbiosis with Obesity-related Osteoarthritis.
Richard F LoeserLiubov ArbeevaKathryn KelleyAnthony A FodorShan SunVeronica UliciLara LongobardiYang CuiDelisha A StewartSusan J SumnerM Andrea Azcarate-PerilR Balfour SartorIan M CarrollJordan B RennerJoanne M JordanAmanda E NelsonPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
The lack of differences in the gut microbiota yet increased serum LPS levels suggest the possibility that increased intestinal permeability allowing for greater absorption of LPS, rather than a dysbiotic microbiota, may contribute to development of OA associated with obesity.