Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.

Zia KhanMin JungMegan CrowRajat MohindraVidya MaiyaJoshua S KaminkerDavid H HackosG Scott ChandlerMark I McCarthyTushar Bhangale

Published in: Genome medicine (2023)

Our genetic study provides insight into the impact of low-frequency and rare coding genetic variation on PN risk and suggests that further study of GPR68 in sensory neurons may yield a therapeutic hypothesis for prevention of CIPN.

Keyphrases

chemotherapy induced
clinical trial
genome wide
spinal cord
randomized controlled trial
copy number
study protocol
open label