Scleroderma fibroblasts suppress angiogenesis via TGF-β/caveolin-1 dependent secretion of pigment epithelium-derived factor.

Vasiliki LiakouliJacobo EliesYasser Mohamed El-SherbinyMargherita ScarciaGary GrantGiuseppina AbignanoEmma C Derrett-SmithFilomena EstevesPaola CiprianiPaul EmeryChristopher P DentonRoberto GiacomelliGeorgia MavriaFrancesco Del Galdo

Published in: Annals of the rheumatic diseases (2017)

Our data reveal a new pathway by which TGF-β suppresses angiogenesis in SSc, through decreased fibroblast Cav-1 expression and subsequent PEDF secretion. This pathway may present a promising target for new therapeutic interventions in SSc.

Keyphrases

endothelial cells
transforming growth factor
vascular endothelial growth factor
wound healing
poor prognosis
systemic sclerosis
physical activity
signaling pathway
big data
epithelial mesenchymal transition
extracellular matrix
interstitial lung disease
gene expression
artificial intelligence