Beneficial effects of transdermal administration of tamoxifen on capsular contracture after breast implantation in murine models.
Miki OkazakiMasako MugurumaTakako KomiyaKana MiyaharaTakahiko KawateAi UedaSaeko TeraokaMariko AsaokaEiichi SatoHajime MatsumuraTakashi IshikawaPublished in: Breast cancer (Tokyo, Japan) (2022)
The transdermal administration of 0.1% and 0.2% 4-OH TAM gels inhibited capsule development. The inhibition of TGF-β expression is a mechanism by which 4-OH TAM suppresses fibroblast growth, preventing capsular formation.