Synergistic inhibitory effects of clopidogrel and rivaroxaban on platelet function and platelet-dependent thrombin generation in cats.

Sara T Lo Ronald H L LiCatherine J GeorgesNghi NguyenCheyenne K ChenClaire StuhlmannMaureen Sigmund OldachVictor Noel RivasSamantha FousseSamantha P HarrisJoshua A Stern

Published in: Journal of veterinary internal medicine (2023)

Treatment combining clopidogrel and rivaroxaban (DAT) safely decreases platelet activation, platelet response to agonists, and thrombin generation in feline platelets more effectively than monotherapy with either clopidogrel or rivaroxaban.

Keyphrases

acute coronary syndrome
venous thromboembolism
atrial fibrillation
percutaneous coronary intervention
pulmonary embolism
antiplatelet therapy
combination therapy
clinical trial
randomized controlled trial
coronary artery disease
smoking cessation
replacement therapy