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Genome-Wide Association Study for the Genetic Determinants of Thiopurine Methyltransferase Protein Expression in Human Livers and Racial Differences.

Logan S SmithXinwen WangJian ShiBing HeHao-Jie Zhu
Published in: Pharmaceutical research (2023)
The GWAS identified 31 SNPs associated with TPMT protein expression in human livers. Hepatic TPMT protein expression was significantly lower in subjects carrying the TPMT*3A, TPMT*3C, and TPMT*24 alleles compared to non-carriers. European ancestry was associated with significantly higher hepatic TPMT protein expression than African ancestry, independent of known TPMT variants.
Keyphrases
  • genome wide association study
  • endothelial cells
  • genome wide
  • copy number
  • dna methylation