Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma.

Chenwei WangYadi LiaoWei HeHong ZhangDinglan ZuoWenwu LiuZhiwen YangJiliang QiuYichuan YuanKai LiYuanping ZhangYongjin WangYunxing ShiYuxiong QiuSong GaoYunfei YuanBin-Kui Li

Published in: Journal of experimental & clinical cancer research : CR (2021)

Upregulation of Elafin by Sp1 enhanced HCC metastasis via EGFR/AKT pathway, and overexpression of Elafin attenuated the anti-metastatic effects of erlotinib, suggesting a valuable prognostic biomarker and therapeutic target for HCC.

Keyphrases

epidermal growth factor receptor
small cell lung cancer
cell proliferation
advanced non small cell lung cancer
tyrosine kinase
squamous cell carcinoma
signaling pathway
poor prognosis
transcription factor