Protective effect of sucupira oil nanoemulsion against oxidative stress in UVA-irradiated HaCaT cells.
Maiulle T PachecoArtur C G SilvaThais L NascimentoDanielle G A DinizMarize C ValadaresEliana Martins LimaPublished in: The Journal of pharmacy and pharmacology (2019)
A novel, stable and easily prepared formulation was obtained for encapsulation of sucupira oil. The protective effect of the formulation by cytokine inhibition in the early stage of the inflammatory process was shown in vitro. Combined with the antioxidant effect by inhibition of reactive oxygen species, the use of sucupira oil NE for prevention and treatment of UVA-induced stress could contribute to decrease the effects of UV radiation on skin ageing.
Keyphrases
- oxidative stress
- induced apoptosis
- diabetic rats
- early stage
- reactive oxygen species
- drug delivery
- fatty acid
- dna damage
- cell cycle arrest
- ischemia reperfusion injury
- high glucose
- soft tissue
- signaling pathway
- cell proliferation
- radiation therapy
- endothelial cells
- squamous cell carcinoma
- combination therapy
- wound healing
- stress induced
- lymph node
- replacement therapy
- heat shock protein
- locally advanced