Androgen increases klotho expression via the androgen receptor-mediated pathway to induce GCs apoptosis.

Xin ZengQiaoqing ZhongMing LiYating LiuShuanglian LongYuanjie XieZhongcheng Mo

Published in: Journal of ovarian research (2023)

Our results demonstrated TP mediates the expression of klotho via androgen receptor and klotho alterations could be a reason for ovarian dysfunction in PCOS.

Keyphrases

poor prognosis
oxidative stress
binding protein
endoplasmic reticulum stress
long non coding rna
polycystic ovary syndrome
type diabetes
cell cycle arrest
metabolic syndrome
signaling pathway