An Expanded EDA Complex Profile: Construction of Aza-arenes and Their Synthetic Application as Fluorescence Probes.
Qun-Liang ZhangBing SunGuanchang JiGuizhen ZhangFang-Lin ZhangPublished in: Organic letters (2023)
We developed a visible-light-driven expanded EDA complex profile for the synthesis of aza-arenes via aza-6π electrocyclization of 2-styrylanilines with aromatic aldehydes. This protocol relies on the EDA complexes of AlCl 3 with imine to induce the absorption red-shift to visible light from ultraviolet light. An array of 2,3-disubstituted quinolines were constructed smoothly after excitation with blue-light-emitting diodes at room temperature. In addition, the resultant product, used as a cell permeable lipid droplet-specific probe, shows a low working concentration, a short staining time, and functionality in living and fixed cells.
Keyphrases
- visible light
- room temperature
- single cell
- induced apoptosis
- high throughput
- living cells
- single molecule
- ionic liquid
- energy transfer
- cell cycle arrest
- randomized controlled trial
- small molecule
- wastewater treatment
- cell therapy
- high resolution
- quantum dots
- oxidative stress
- signaling pathway
- cell death
- stem cells
- amino acid
- mesenchymal stem cells
- fluorescent probe
- bone marrow
- pi k akt