A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation.
Chandra A ReynoldsQihua TanElizabeth MunozJuulia JylhäväJacob HjelmborgLene ChristiansenSara HäggNancy L PedersenPublished in: Aging cell (2020)
Across time, stability in methylation is primarily due to genetic contributions, while novel experiences and exposures contribute to methylation differences. Elevated genetic contributions at age-related methylation sites suggest that adaptions to aging and senescence may be differentially impacted by genetic background.