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A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation.

Chandra A ReynoldsQihua TanElizabeth MunozJuulia JylhäväJacob HjelmborgLene ChristiansenSara HäggNancy L Pedersen
Published in: Aging cell (2020)
Across time, stability in methylation is primarily due to genetic contributions, while novel experiences and exposures contribute to methylation differences. Elevated genetic contributions at age-related methylation sites suggest that adaptions to aging and senescence may be differentially impacted by genetic background.
Keyphrases
  • genome wide
  • dna methylation
  • copy number
  • gene expression
  • air pollution
  • cross sectional
  • risk assessment