A decade of epigenetic change in aging twins: Genetic and environmental contributions to longitudinal DNA methylation.

Chandra A ReynoldsQihua TanElizabeth MunozJuulia JylhäväJacob HjelmborgLene ChristiansenSara HäggNancy L Pedersen

Published in: Aging cell (2020)

Across time, stability in methylation is primarily due to genetic contributions, while novel experiences and exposures contribute to methylation differences. Elevated genetic contributions at age-related methylation sites suggest that adaptions to aging and senescence may be differentially impacted by genetic background.

Keyphrases

genome wide
dna methylation
copy number
gene expression
air pollution
cross sectional
risk assessment