DLPFC volume is a neural correlate of resilience in healthy high-risk individuals with both childhood maltreatment and familial risk for depression.
Katharina BroschFrederike SteinTina MellerSimon SchmittDilara YukselKai Gustav RingwaldJulia-Katharina PfarrLena WaltemateHannah LemkeNils OpelSusanne MeinertKatharina DohmDominik GrotegerdJanik GoltermannJonathan ReppleAlexandra WinterAndreas JansenUdo DannlowskiIgor NenadićTilo KircherAxel KrugPublished in: Psychological medicine (2021)
The healthy high-risk group had significantly higher volumes in the left DLPFC compared to all other groups. The DLPFC is implicated in cognitive and emotional processes, and higher volume in this area might aid high-risk individuals in adaptive coping in order to maintain mental health. This increased volume might therefore constitute a neural correlate of resilience to MDD in high risk.