Novel Clinical Tool to Estimate Risk of False-Negative KRAS Mutations in Circulating Tumor DNA Testing.
Stefania NapolitanoAparna Raj ParikhJason T HenryChristine M ParseghianJason WillisKanwal P S RaghavVan Karlyle MorrisBenny JohnsonBryan K KeeArvind N DasariMichael James OvermanRaja LuthraLeylah M DrusboskyRyan B CorcoranEdmund S KopetzRyan SunPublished in: JCO precision oncology (2023)
) is observed; usage may be especially important for subjects with a maximum reference frequency of <8%. Extension of the methodology to predict false negatives of other genes is possible. Additional reference genes can also be considered. Use of personal training data sets is supported. An open-source R Shiny application is available for public use.