Spatiotemporal formation of glands in plants is modulated by MYB-like transcription factors.
Jiang ChangShurong WuTing YouJianfeng WangBingjing SunBojun XuXiaochun XuYaping ZhangShuang WuPublished in: Nature communications (2024)
About one third of vascular plants develop glandular trichomes, which produce defensive compounds that repel herbivores and act as a natural biofactory for important pharmaceuticals such as artemisinin and cannabinoids. However, only a few regulators of glandular structures have been characterized so far. Here we have identified two closely-related MYB-like genes that redundantly inhibit the formation of glandular cells in tomatoes, and they are named as GLAND CELL REPRESSOR (GCR) 1 and 2. The GCR genes highly express in the apical cells of tomato trichomes, with expression gradually diminishing as the cells transition into glands. The spatiotemporal expression of GCR genes is coordinated by a two-step inhibition process mediated by SlTOE1B and GCRs. Furthermore, we demonstrate that the GCR genes act by suppressing Leafless (LFS), a gene that promotes gland formation. Intriguingly, homologous GCR genes from tobacco and petunia also inhibit gland formation, suggesting that the GCR-mediated repression mechanism likely represents a conserved regulatory pathway for glands across different plant species.
Keyphrases
- transcription factor
- genome wide identification
- genome wide
- induced apoptosis
- cell cycle arrest
- poor prognosis
- bioinformatics analysis
- stem cells
- endoplasmic reticulum stress
- cell death
- high resolution
- signaling pathway
- dna binding
- binding protein
- dna repair
- mass spectrometry
- long non coding rna
- cell therapy
- bone marrow
- pi k akt