CEMIP (HYBID, KIAA1199): structure, function and expression in health and disease.
Sofia SpataroConcetta GuerraAndrea CavalliJacopo SgrignaniJonathan Paul SleemanLina PoulainAndreas BolandLeonardo ScapozzaSolange MollMarco PrunottoPublished in: The FEBS journal (2022)
CEMIP (cell migration-inducing protein), also known as KIAA1199 or HYBID, is a protein involved in the depolymerisation of hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix. CEMIP was originally described in patients affected by nonsyndromic hearing loss and has subsequently been shown to play a key role in tumour initiation and progression, as well as arthritis, atherosclerosis and idiopathic pulmonary fibrosis. Despite the vast literature associating CEMIP with these diseases, its biology remains elusive. The present review article summarises all the major scientific evidence regarding its structure, function, role and expression, and attempts to cast light on a protein that modulates EMT, fibrosis and tissue inflammation, an unmet key aspect in several inflammatory disease conditions.
Keyphrases
- idiopathic pulmonary fibrosis
- extracellular matrix
- hyaluronic acid
- cell migration
- binding protein
- poor prognosis
- protein protein
- oxidative stress
- healthcare
- ejection fraction
- amino acid
- public health
- newly diagnosed
- cardiovascular disease
- hearing loss
- systematic review
- epithelial mesenchymal transition
- type diabetes
- mental health
- prognostic factors
- interstitial lung disease
- health information
- chronic kidney disease
- climate change
- systemic sclerosis