Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via CX3CR1/AMPK/PPARγ Pathway After GMH.
Xionghui ChenXuying HeFeng XuNingbo XuNona Hashem SharifiPengjie ZhangJerry J FloresLei WuQiuguang HeHideki KanamaruShiyi ZhuSiyuan DongMingyang HanYe YuanLei HuangLiyan MiaoArne P NeyrinckYouxin ZhouJi-Ping TangPublished in: Stroke (2023)
CX3CR1 activation by r-FKN promoted hematoma resolution, attenuated neuroinflammation, and neurological deficits partially through the AMPK/PPARγ signaling pathway, which promoted M1/M2 microglial polarization. Activating CX3CR1 by r-FKN may provide a promising therapeutic approach for treating patients with GMH.
Keyphrases
- signaling pathway
- traumatic brain injury
- lipopolysaccharide induced
- skeletal muscle
- lps induced
- insulin resistance
- single molecule
- cerebral ischemia
- pi k akt
- inflammatory response
- epithelial mesenchymal transition
- fatty acid
- type diabetes
- induced apoptosis
- cognitive impairment
- cell proliferation
- metabolic syndrome
- spinal cord injury
- subarachnoid hemorrhage
- blood brain barrier
- endoplasmic reticulum stress