Fecal microbiota from patients with Parkinson's disease intensifies inflammation and neurodegeneration in A53T mice.

Huijia YangYaping ShaoYiying HuJin QianPanpan WangLulu TianYang NiSong LiMurad Al-NusaifCong LiuWei-Dong Le

Published in: CNS neuroscience & therapeutics (2024)

The fecal microbiota from PD patients intensifies inflammation and neurodegeneration in A53T mice. Our findings demonstrate that imbalance and dysfunction in the gut microbiome play significant roles in the development and advancement of PD.

Keyphrases

oxidative stress
end stage renal disease
ejection fraction
high fat diet induced
prognostic factors
patient reported outcomes
wild type