A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16.
Chao ZhengDaniel HoldenMing-Qiang ZhengRichard PracittoKyle C WilcoxMarcel LindemannZachary FelchnerLi ZhangJie TongKrista FowlesSjoerd J FinnemaNabeel NabulsiRichard E CarsonYiyun HuangZhengxin CaiPublished in: European journal of nuclear medicine and molecular imaging (2021)
We have successfully synthesized a novel SV2A PET tracer [18F]SDM-16, which has the highest SV2A binding affinity and metabolical stability among published SV2A PET tracers. The [18F]SDM-16 brain PET images showed superb contrast between gray matter and white matter. Moreover, [18F]SDM-16 showed high specific and reversible binding in the NHP brains, allowing for the reliable and sensitive quantification of SV2A, and has potential applications in the visualization and quantification of SV2A beyond the brain.
Keyphrases
- positron emission tomography
- white matter
- pet imaging
- computed tomography
- pet ct
- resting state
- binding protein
- magnetic resonance
- multiple sclerosis
- high resolution
- functional connectivity
- randomized controlled trial
- convolutional neural network
- risk assessment
- optical coherence tomography
- mesenchymal stem cells
- cerebral ischemia
- brain injury
- machine learning
- human health
- amino acid
- meta analyses