Determinants of fluid use and the association between volume of fluid used and effect of balanced solutions on mortality in critically ill patients: a secondary analysis of the BaSICS trial.
Fernando Godinho ZampieriFlavia R MachadoVivivane C VeigaLuciano C P AzevedoSean M BagshawLucas P DamianiAlexandre B CavalcantiPublished in: Intensive care medicine (2023)
Baseline patient characteristics collected in the BaSICS trial explain less of the variance of fluid use during the first 3 days than the enrolling site. Volume of fluid used and the effects of BS appear to interact, mostly in the sepsis subgroup where there was a strong association between fluid use after enrollment and the effect of BS on 90-day mortality.