Rottlerin, a natural polyphenol compound, inhibits upregulation of matrix metalloproteinase-9 and brain astrocytic migration by reducing PKC-δ-dependent ROS signal.

Tsong-Hai LeeJiun-Liang ChenPei-Shan LiuMing-Ming TsaiSu-Jane WangHsi-Lung Hsieh

Published in: Journal of neuroinflammation (2020)

These data indicated that rottlerin may have anti-inflammatory activity by reducing these related pathways of PKC-δ-dependent ROS-mediated MMP-9 expression in brain astrocytes.

Keyphrases

poor prognosis
resting state
white matter
cell death
dna damage
reactive oxygen species
functional connectivity
cell proliferation
cerebral ischemia
long non coding rna
electronic health record
signaling pathway
big data
machine learning
blood brain barrier
drug induced