Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia.

Liuluan ZhuYaxian KongJianhong ZhangDavid F ClaxtonW Christopher EhmannWitold B RybkaNeil D PalmisianoMing WangBei JiaMichael BayerlTodd D SchellRaymond J HohlHui ZengHong Zheng

Published in: Journal of hematology & oncology (2017)

Our study demonstrates an important inhibitory effect of Blimp-1 on T cell response in AML; thus, targeting Blimp-1 and its regulated molecules to improve the immune response may provide effective leukemia therapeutics.

Keyphrases

acute myeloid leukemia
immune response
allogeneic hematopoietic stem cell transplantation
transcription factor
small molecule
poor prognosis
signaling pathway
cancer therapy
dendritic cells
acute lymphoblastic leukemia
long non coding rna