SIRT3/AMPK signaling pathway regulates lipid metabolism and improves vulnerability to atrial fibrillation in Dahl salt sensitive rats.
Xiu-Heng WangZhi-Hong NingZhong XieYun OuJia-Yang YangYun-Xi LiuHong HuangHui-Fang TangZhi-Sheng JiangHeng-Jing HuPublished in: American journal of hypertension (2024)
We have confirmed that high-salt diet can result in hypertension, associated atrial tissue lipid metabolism dysfunction. This condition is linked to the inhibition of the SIRT3/AMPK signaling pathway, which plays a significant role in the progression of susceptibility to AF in SSHT rats.
Keyphrases
- atrial fibrillation
- signaling pathway
- oxidative stress
- pi k akt
- catheter ablation
- left atrial
- skeletal muscle
- blood pressure
- oral anticoagulants
- epithelial mesenchymal transition
- ischemia reperfusion injury
- left atrial appendage
- direct oral anticoagulants
- induced apoptosis
- heart failure
- physical activity
- climate change
- fatty acid
- protein kinase
- weight loss
- coronary artery disease
- cell proliferation
- acute coronary syndrome