Immunophenotype and antitumor activity of cytokine-induced killer cells from patients with hepatocellular carcinoma.
Chan-Keng YangChien-Hao HuangChing-Hsun HuJian-He FangTse-Ching ChenYung-Chang LinYung-Chang LinPublished in: PloS one (2023)
This study revealed that CIK cells from HCC patients possess cytotoxic properties, and express increased levels of effector NK receptors and chemokine molecules and lower levels of suppressive checkpoint receptors. CIK cells can suppress human HCC ex-vivo and in vivo. Future clinical trials of human CIK cell therapy for HCC are warranted.
Keyphrases
- endothelial cells
- clinical trial
- end stage renal disease
- single cell
- high glucose
- induced apoptosis
- chronic kidney disease
- induced pluripotent stem cells
- newly diagnosed
- pluripotent stem cells
- prognostic factors
- cell cycle
- dendritic cells
- diabetic rats
- cell cycle arrest
- oxidative stress
- cell death
- immune response
- current status
- cell proliferation
- endoplasmic reticulum stress
- phase ii
- phase iii