CRISPR screens identify gene targets at breast cancer risk loci.

Natasha K TuanoJonathan BeesleyMurray ManningWei ShiLaura Perlaza-JimenezLuis F Malaver-OrtegaJacob M PaynterDebra BlackAndrew CivitareseKaren McCueAaron HatzipantelisKristine HillmanSusanne KaufmannHaran SivakumaranJose M PoloRoger R ReddelVimla BandJuliet D FrenchStacey L EdwardsDavid R PowellGeorgia Chenevix-TrenchJoseph Rosenbluh

Published in: Genome biology (2023)

We demonstrate that phenotypic CRISPR screens can accurately pinpoint the gene target of a risk locus. In addition to defining gene targets of risk loci associated with increased breast cancer risk, we provide a platform for identifying gene targets and phenotypes mediated by risk variants.

Keyphrases

genome wide
breast cancer risk
copy number
dna methylation
high throughput
genome wide identification
crispr cas
genome editing