Single-photon emission computed tomography/computed tomography imaging of RAGE in smoking-induced lung injury.
Monica P GoldklangYared TekabeTina ZeloninaJordis TrischlerRui XiaoKyle StearnsKrissy RodriguezAlexander ShieldsAlexander RomanovJeanine M D'ArmientoLynne L JohnsonPublished in: Respiratory research (2019)
RAGE-directed imaging identified pulmonary RAGE expression acutely in vivo in an animal model of emphysema early after smoke exposure, with diminution over time. These studies document the extent and time course of RAGE expression under smoke exposure conditions and could be utilized for disease monitoring and examining response to future RAGE-targeted therapies.
Keyphrases
- computed tomography
- poor prognosis
- high resolution
- positron emission tomography
- magnetic resonance imaging
- pulmonary hypertension
- chronic obstructive pulmonary disease
- binding protein
- smoking cessation
- contrast enhanced
- high glucose
- long non coding rna
- drug induced
- mass spectrometry
- image quality
- magnetic resonance
- dual energy
- idiopathic pulmonary fibrosis
- air pollution
- case control