Aspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma.
Borbála SzabóKinga NémethKatalin MészárosLilla KrokkerIstván LikóÉva SaskőiKrisztina NémethPál Tamás SzabóNikolette SzücsSándor CzirjákGábor SzalókiAttila PatócsHenriett ButzPublished in: The Journal of clinical endocrinology and metabolism (2022)
A novel regulatory network has been revealed, in which aspirin regulated global demethylation, Tp53 activity, and Pttg1 expression along with decreased cell proliferation and migration. 5hmC, a novel tissue biomarker in PitNET, indicated aspirin antitumoral effect in vitro as well. Our findings suggest the potential beneficial effect of aspirin in PitNET.