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Aspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma.

Borbála SzabóKinga NémethKatalin MészárosLilla KrokkerIstván LikóÉva SaskőiKrisztina NémethPál Tamás SzabóNikolette SzücsSándor CzirjákGábor SzalókiAttila PatócsHenriett Butz
Published in: The Journal of clinical endocrinology and metabolism (2022)
A novel regulatory network has been revealed, in which aspirin regulated global demethylation, Tp53 activity, and Pttg1 expression along with decreased cell proliferation and migration. 5hmC, a novel tissue biomarker in PitNET, indicated aspirin antitumoral effect in vitro as well. Our findings suggest the potential beneficial effect of aspirin in PitNET.
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