Aspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma.

Borbála SzabóKinga NémethKatalin MészárosLilla KrokkerIstván LikóÉva SaskőiKrisztina NémethPál Tamás SzabóNikolette SzücsSándor CzirjákGábor SzalókiAttila PatócsHenriett Butz

Published in: The Journal of clinical endocrinology and metabolism (2022)

A novel regulatory network has been revealed, in which aspirin regulated global demethylation, Tp53 activity, and Pttg1 expression along with decreased cell proliferation and migration. 5hmC, a novel tissue biomarker in PitNET, indicated aspirin antitumoral effect in vitro as well. Our findings suggest the potential beneficial effect of aspirin in PitNET.

Keyphrases

low dose
cardiovascular events
antiplatelet therapy
single cell
transcription factor
poor prognosis
signaling pathway
coronary artery disease
type diabetes
stem cells
atrial fibrillation
human health
growth hormone