Distinct variations of antibody secreting cells and memory B cells during the course of Kawasaki disease.
Meng XuYanfang JiangJinghua WangJinxiang LiuCongcong LiuDeying LiuSi-Rui YangPublished in: BMC immunology (2019)
Our study provided direct evidence that ASCs contributed to the pathogenesis of KD, and it was the first time to describe the variation of memory B cells in this disease. Among the subsets, only IgG+ ASCs presented a significant increase in the acute stage and decreased after IVIG administration, indicating the involvement of IgG+ ASCs in the inflammation of KD and also suggesting that IVIG played an inhibitory role in the expression of cytoplasmic IgG.