Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.

Enquan XuRavindra BodduHisham A AbdelmotilibArpine SokratianKaela KellyZhiyong LiuNicole BryantSidhanth ChandraSamantha M CarlisleElliot J LefkowitzAshley S HarmsEtty N BenvenisteTalene A YacoubianLaura A Volpicelli-DaleyDavid G StandaertAndrew B West

Published in: Molecular neurodegeneration (2022)

Pathologic α-synuclein activates LRRK2 expression and kinase activity in monocytes and induces their recruitment to the brain. These results predict that LRRK2 kinase inhibition may attenuate damaging pro-inflammatory monocyte responses in the brain.

Keyphrases

resting state
white matter
dendritic cells
peripheral blood
functional connectivity
poor prognosis
cerebral ischemia
protein kinase
tyrosine kinase
neoadjuvant chemotherapy
multiple sclerosis
squamous cell carcinoma
radiation therapy
locally advanced
binding protein
rectal cancer