TGFβ-mediated expression of TGFβ-activating integrins in SSc monocytes: disturbed activation of latent TGFβ?
Arjan P M van CaamJ AartsT van EeE VittersM KoendersF van de LooP van LentF van den HoogenR ThurlingsM C VonkP M van der KraanPublished in: Arthritis research & therapy (2020)
Total TGFβ serum levels are not different between SSc patients and controls, but TGFβ activity is. This coincides with a reduced expression of TGFβ-activating integrins in monocytes of SSc patients. Because TGFβ regulates expression of these integrins in monocytes, a negative feedback mechanism possibly underlies these observations.