Quantifying trial-by-trial variability during cortico-cortical evoked potential mapping of epileptogenic tissue.
Eli J CornblathAlfredo LucasCaren ArmstrongAdam S GreenblattJoel M SteinPeter N HadarRamya RaghupathiEric MarshBrian LittKathryn A DavisErin C ConradPublished in: Epilepsia (2023)
These findings suggest that standard approaches for CCEP mapping, which involve computing a trial-averaged response over a 0.2-1 Hz stimulation train, may be masking inter-trial variability that localizes to epileptogenic tissue. We also found that CCEP N1 ampli- tudes synchronize with ongoing low frequency oscillations in the hippocampus. Further targeted experiments are needed to determine whether phase-locked stimulation could have a role in localizing epileptogenic tissue.