A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol.

Kathryn CurtisMichael MooreChristie CabralVasa CurcinJeremey HorwoodRichard MorrisVibhore PrasadAnne SchilderNicholas TurnerScott WilkesAlastair D HayJodi Taylor

Published in: Trials (2020)

Name of Registry: ISCRTN Registration Number: ISRCTN12873692. This contains all items required to comply with the World Health Organization Trial Registration Data Set Date of Registration: 24 April 2018 Name of Registry: EudraCT Registration Number: 2017-003635-10 Date of Registration: 6 September 2017.

Keyphrases

study protocol
clinical trial
randomized controlled trial
open label
phase iii
phase ii
young adults
minimally invasive
double blind
big data
intensive care unit
extracorporeal membrane oxygenation
acute respiratory distress syndrome
artificial intelligence
aortic dissection
deep learning