High-Throughput RNA Sequencing Reveals the Effect of NB-UVB Phototherapy on Major Inflammatory Molecules of Lesional Psoriasis.
Pinyadapat VacharanukrauhJitlada MeephansanPattarin TangtanatakulWipasiri SoonthornchaiJongkonnee WongpiyabovornOnsiri SeriratMayumi KominePublished in: Psoriasis (Auckland, N.Z.) (2021)
NB-UVB is an effective treatment for psoriasis. Our study supports the conclusion that the clinical effectiveness of NB-UVB therapy is based on the suppression of a broad range of inflammatory signaling pathways, gene expression of inflammatory cytokines and increased expressions of anti-inflammatory signaling pathways in psoriatic skin. This is the first study that applied advanced molecular techniques to investigate phototherapy as a new key to unlock genetic knowledge and create novel information. Ultimately, the goal is to increase medical knowledge and improve the patient care of psoriasis.
Keyphrases
- gene expression
- healthcare
- high throughput
- signaling pathway
- anti inflammatory
- oxidative stress
- rheumatoid arthritis
- systematic review
- single cell
- dna methylation
- randomized controlled trial
- stem cells
- pi k akt
- systemic lupus erythematosus
- atopic dermatitis
- mesenchymal stem cells
- cell proliferation
- endoplasmic reticulum stress
- combination therapy
- chemotherapy induced