Pancreatic neuroendocrine tumor progression and resistance to everolimus: the crucial role of NF-kB and STAT3 interplay.

Eleonora VitaliG ValenteA PanzardiA LaffiA ZerbiS UccellaG MazziottiA Lania

Published in: Journal of endocrinological investigation (2023)

Since the NF-kB pathway is implicated in Pa-NETs' progression and resistance to everolimus, these data could explain the potential use of NF-kB as a novel therapeutic target in Pa-NET patients.

Keyphrases

signaling pathway
lps induced
pi k akt
end stage renal disease
nuclear factor
oxidative stress
ejection fraction
newly diagnosed
chronic kidney disease
cell proliferation
prognostic factors
poor prognosis
patient reported outcomes
long non coding rna
patient reported
data analysis