Evaluating [ 225 Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice.

Marco F TaddioSuraj DoshiMarwan MasriPauline JeanjeanFiras HikmatAlana GerlachLea NyiranshutiEthan W RosserDorthe SchaueElie Besserer-OffroyGiuseppe CarlucciCaius G RaduJohannes CzerninKatharina LückerathChristine E Mona

Published in: European journal of nuclear medicine and molecular imaging (2024)

Ac]Ac-FAPI-46 efficacy is correlated with tumoral FAP expression levels and can restore responsiveness to PD-1 ICB. These data illustrate that careful patient selection based on target expression and rationally designed combination therapies are critically important to maximize the therapeutic impact of FAP-targeting radioligands.

Keyphrases

poor prognosis
binding protein
electronic health record
case report
long non coding rna
cancer therapy
big data
metabolic syndrome
high fat diet induced
machine learning
drug delivery