5-aminolevulinic acid photodynamic therapy for the treatment of high-grade gliomas.

K MahmoudiK L GarveyA BourasG CramerH SteppJ G Jesu RajD BozecT M BuschConstantinos G Hadjipanayis

Published in: Journal of neuro-oncology (2019)

PDT remains a promising therapeutic approach that requires further study in HGGs. Use of 5-ALA PDT permits selective tumor targeting due to the intracellular metabolism of 5-ALA. The immunomodulatory effects of PDT further strengthen its use for treatment of HGGs and requires a better understanding. The combination of PDT with adjuvant therapies for HGGs will need to be studied in randomized, controlled studies.

Keyphrases

photodynamic therapy
high grade
cancer therapy
early stage
low grade
randomized controlled trial
clinical trial
double blind
drug delivery
study protocol
phase ii
case control